Image: CAPON Binds Nitric Oxide Synthase, Regulating NMDA Receptor–Mediated Glutamate Neurotransmission

Description: Binding of CAPON results in a reduction of NMDA receptor/nitric oxide synthase (NOS) complexes, leading to decreased NMDA receptor–gated calcium influx and a catalytically inactive nitric oxide synthase. Overexpression of either the full-length or the novel shortened CAPON isoform as reported by Brzustowicz and colleagues is, therefore, predicted to lead to impaired NMDA receptor–mediated glutamate neurotransmission.
Title: CAPON Binds Nitric Oxide Synthase, Regulating NMDA Receptor–Mediated Glutamate Neurotransmission
Credit: Does the CAPON Gene Confer Susceptibility to Schizophrenia?
Author: Bang Wong
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