Image: HIF Nobel Prize Physiology Medicine 2019 Hegasy ENG

Size of this preview: 800 × 566 pixels. Other resolutions: 320 × 226 pixels | 3,508 × 2,480 pixels.

Original image ‎(3,508 × 2,480 pixels, file size: 1.26 MB, MIME type: image/png)

Description: Nobel Prize in Physiology or Medicine 2019: How Cells Sense and Adapt to Oxygen Availability. Under normoxic conditions, Hif-1 alpha is hydroxylated at two proline residues. The protein then associates with VHL and is subsequently tagged with ubiquitin. Tagged Hif-1 alpha is then translocated to the proteasome, where it is degraded. Under hypoxic conditions, no oxygen is available for proline hydroxylation. In this situation Hif-1 alpha translocates to the cell nucleus and associates with Hif-1 beta, also termed ARNT. This complex then binds to a DNA region termed HRE (hypoxia responsive element). As a consequence target genes are transcribed. These genes are involved in the regulation of a multitude of processes, including erythropoesis, glycolysis and angiogenesis.
Title: HIF Nobel Prize Physiology Medicine 2019 Hegasy ENG
Credit: Own work
Author: Dr. Guido Hegasy
Usage Terms: Creative Commons Attribution-Share Alike 3.0
License: CC BY-SA 3.0
License Link: https://creativecommons.org/licenses/by-sa/3.0
Attribution Required?: Yes

Image usage

The following 3 pages link to this image:

All content from Kiddle encyclopedia articles (including the article images and facts) can be freely used under Attribution-ShareAlike license, unless stated otherwise.