Image: In vivo AO 2PFM visualized features of epithelium and fiber cell organization in the mouse lens

Description: In vivo AO 2PFM visualizes features of epithelium and fiber cell organization in mouse lenses. (A-I) Representative images of cellular features at various depths visualized by AO 2PFM in the anterior lenses of the mice employed in the study. (A) Lens epithelium, (B) disorganized and broadened fiber cell ends, (C) non-uniform superficial fiber cells with excessive interdigitation, (D, F) anterior voids, (E, G) mostly uniform rows of fiber cells with enlarged vacuoles, (H, I) tight suture structures at depth. Depth noted in each panel is relative to the epithelium. Arrowheads point to features described in the main text. Scale bar: 50 μm.
Title: In vivo AO 2PFM visualized features of epithelium and fiber cell organization in the mouse lens
Credit: Version 1. bioRxiv. Preprint. 2023 Jan 19. doi: 10.1101/2023.01.17.524320 PMCID: PMC9882239 PMID: 36711806
Author: Santosh Kumar Paidi,1 Qinrong Zhang,2,3 Yuhan Yang,2 Chun-Hong Xia,1,4 Na Ji,2,3,5,6,7 and Xiaohua Gong1,4,7 1School of Optometry, University of California, Berkeley, California 94720, USA 2Department of Physics, University of California, Berkeley, California 94720, USA 3Department of Molecular and Cell Biology, University of California, Berkeley, CA 94720, USA 4Vision Science Program, University of California, Berkeley, California 94720, USA 5Helen Wills Neuroscience Institute, University of California, Berkeley, CA 94720, USA 6Molecular Biophysics and Integrated Bioimaging Division, Lawrence Berkeley National Laboratory, Berkeley, CA 94720, USA
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