Image: Transformer splicing

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Description: Alternative splicing of the Transformer gene transcript in Drosophila melanogaster. In males, the splicing factor U2AF binds to the 3' splice junction of intron 1, allowing the transcript to be spliced at this point. The mRNA then contains the entire exon 2, including an early stop codon. The protein encoded is truncated and non-functional. In females, the master sex determination factor Sex Lethal (Sxl) binds at the 3' splice junction, competing with U2AF. Splicing then occurs at an alternative 3' splice junction within exon 2. The mRNA that results encodes a functional Tra protein.
Title: Transformer splicing
Credit: Own work
Author: Agathman
Usage Terms: Creative Commons Attribution 3.0
License: CC BY 3.0
License Link: http://creativecommons.org/licenses/by/3.0
Attribution Required?: Yes

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Alternative splicing

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